代謝
代謝疾病包括高血糖、高膽固醇、高血脂和肥胖等，是現代社會中重要的健康問題。 我們目前可以提供的活體代謝相關測量包括體重，食量，glucose tolerance test, insulin tolerance test, fasted bleed, metabolic cages等。
以下為建議提供的模式動物：
| Disease | Model | Phenotype |
| Disease Model Phenotype Type II Diabetes | ob/ob or db/db (genetic model) | ob/ob is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. Mutant mice gain weight rapidly throughout their lives, reaching a weight three times that of unaffected mice. ob/ob mice develop high blood sugar, despite an enlargement of the pancreatic islets and increased levels of insulin. db/db mice express mutations in leptin receptor that lead to decreased insulin receptor sensitivity and subsequent increased levels of blood glucose, decreased β-cell function, increased obesity and elevated HBA1c levels. |
| Type I Diabetes | NOD (genetic model) | The NOD/ShiLtJ strain (commonly called NOD) is a polygenic model for autoimmune type 1 diabetes. Diabetes in NOD mice is characterized by hyperglycemia and insulitis, a leukocytic infiltration of the pancreatic islets. Marked decreases in pancreatic insulin content occur in females at about 12 weeks of age and several weeks later in males |
| obesity | High fat diet-induced | C57BL/6 is among the most sensitive to this diet-induced obesity (DIO). C57BL/6-DIO mice, particularly males, develop severe obesity, increased glucose intolerance, moderate insulin resistance and elevated glucose levels, but they typically do not develop basal hyperglycemia (from JAX). |
| Dysregulated metabolism and insulin resistant | IfitmDel (genetic model) | The IfitmDel mouse lacks all five of the Ifitm genes via LoxP deletion. The IfitmDel animals exhibit a steady and significantly enhanced weight gain relative to wild-type controls. The increased weight corresponds with elevated fat mass, and in tolerance tests they are hyporesponsive to insulin but respond normally to glucose. Both young (4 mo) and older (12 mo) IfitmDel mice have enhanced levels of serum leptin. |
